Cytopenias - III. Neutropenia
A. Neutropenia occurs in half of all patients with advanced HIV infection. Causes include myelosuppressive medications, opportunistic infections or neoplasms, HIV-induced myelosuppression, deficient production of myeloid growth-stimulating factors, and depletion of hematopoietic progenitor cells.
B. Neutropenia may cause an increased incidence of infections, hospitalization, decreased survival, and discontinuation of medications (or use of suboptimal dosages).
C. Filgrastim (granulocyte-colony stimulating factor, G-CSF) can increase neutrophil counts, improve neutrophil function and reverse severe neutropenia. G-CSF corrects of neutropenia for long periods of time with induction doses of 1-4 mcg/kg per day, followed by a maintenance dose of 300 mcg 1-7 times per week. voltarol medication
D. Filgrastim increases the absolute neutrophil count (ANC) reduces the risk of bacterial infec-tions, and increases survival. buy penisol online
E. Sargramostim (recombinant granulocyte-macrophage colony-stimulating factor, GM-CSF) at doses of 0.5-8 mcg/kg/day increases circulating leukocyte numbers including increases in granulocytes, monocytes and eosinophils. The use of GM-CSF with myelosuppressive chemotherapy may allow continued chemotherapy for non-Hodgkin’s lymphoma and Kaposi’s sarcoma. Use of GM-CSF often allows for continued use of myelosuppressive antibiotics for opportunistic infections (eg, ganciclovir treatment of CMV retinitis). buy zelnorm online