02 Mar
Gastric Acid Suppression by Proton Pump Inhibitors: DISCUSSION
In studies evaluating PPIs as a risk factor for CDAD, results have been mixed. This relationship has been somewhat ambiguous, and the exact mechanism of action is only speculative. C. difficile is a gram-positive, spore-forming anaerobic bacillus. The spores are acid-resistant, and they are not affected by the gastric pH. By contrast, a vegetative inoculum [...]