02 Aug

Stability of Thiamine in Extemporaneously Compounded Suspensions



Pharmacists prepare “homemade” suspensions for many medications that are not available in dosage forms suitable for children (and adults) who are unable to swallow tablets or capsules. Thiamine (vitamin B1), used in the treatment of metabolic diseases, is one such extemporaneously compounded suspension. Ora-Sweet (a sweetening agent) and Ora-Plus (a suspending agent) are now commercially available (Paddock Laboratories Inc, Minneapolis, Minnesota); these products ease preparation of the suspension and improve palatability. Although the stability of thiamine in other vehicles and dosage forms has been widely reported, there is no published information on the stability of thiamine in 1:1 Ora-Sweet:Ora-Plus.

This study examined the physical characteristics and chemical stability (defined as maintenance of more than 90% of initial concentration) of extemporaneously prepared oral thiamine suspensions of 100 mg/mL in a 1:1 mixture of Ora-Sweet and Ora-Plus, stored at 4°C and 25°C throughout a 91-day study period.
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