Occurred relatively quickly, such that 31% or less of the drug of interest remained at the end of the degradation study period (Table 1). Degradation produced additional peaks in each chromatogram, which could be separated from the drug of interest in each case. Given the chromatographic separation of these degradation products from the drug of [...]
Stability Study On study day 0 for each drug, vials of the particular drug (for which manufacturers, lots, and expiry dates are listed in Table 1) were reconstituted according to the manufacturer’s instructions. The nominal concentrations identified in Table 1 were prepared by diluting the required amount of drug into 50-mL polyvinyl chloride (PVC) minibags [...]
Liquid Chromatographic Method The liquid chromatographic system consisted of an isocratic solvent delivery pump (model P4000; Thermo Separation Products, San Jose, California), which pumped a mixture of acetonitrile (OmniSolv; EMD Chemicals Inc, Gibbstown, New Jersey) and a buffer or other modifiers, as specified in Table 1, through the reverse-phase column, also as specified in Table [...]
INTRODUCTION The expiry date of IV medications after reconstitution or dilution is often limited to about 24 h because of the potential for breaks in sterility. However, when reconstitution and dilution are carried out in a sterile environment, according to recommendations in USP Chapter <797>,’ the expiry dates for many stable compounds can be extended [...]
The first randomized trial of treatments for pulmonary disease caused by M. malmoense was completed by the British Thoracic Society, which compared regimens of rifampicin and ethambutol with rifampicin, ethambutol, and isoniazid. A total of 106 patients with pulmonary infection due to M. malmoense were treated for 2 years. Rifampicin and ethambutol yielded cure rates [...]
Mycobacterium malmoense was first described in 1977 by Schroder and Juhlin on the basis of 4 cases of pulmonary infection in the city of Malmo, Sweden, from which the organism gets its name. Most published case reports have originated in northern Europe and the United Kingdom; however, several reports, most from the United States, have [...]
Upon further examination at the Eastern Health Infectious Diseases clinic in December 2006, the patient’s vital signs were stable, she was afebrile, and there was no hemoptysis. The patient was cachetic with obvious tachypnea, but there were no signs of respiratory distress. On auscultation, the clinician noted decreased breath sounds and scattered crackles in the [...]
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