Introduction Osteoporosis is the most prevalent metabolic bone disease among developed countries and it is defined as a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Its clinical significance lies in the occurrence of fractures, involving most commonly the forearm, the vertebral bodies and the hip, but fractures at other sites [...]
Patients on long term hemodialysis caused by chronic renal failure commonly have accompanying renal bone disease, one of the major factors underlying this disease being secondary hyperparathyroidism. Parathyroid hyperplasia and high levels of immunoreactive PTH are present in the early stage of secondary hyperparathyroidism. Clonal analysis has shown that in renal hyperparathyroidism the parathyroid glands [...]
The frequency distribution of VDR and CaSR genotypes were in Hardy-Weinberg equilibrium. The distribution of Apa I a nd Taq I genotypes was very similar to what previously reported in Caucasian populations of European ancestry, while significantly differed from what observed in populations of Asiatic ancestry. The distribution of CaSR genotypes did not vary from [...]
Subjects The study population comprised 100 patients affected with uremic secondary HPT and 200 age and sex matched controls. Patients had been recruited as part of a multicentric Italian study, including the Nephrology and Dyalisis Units of Bari, Cinisello Balsamo, Desio, Florence, Milan and Reggio Emilia. The inclusion criteria for the study were the following: [...]
Introduction The pathophysiology of hyperparathyroidism (HPT) relates to the loss of normal feedback control of parathyroid hormone secretion by extracellular calcium. However, why the parathyroid cell loses its normal sensivity to calcium is unknown. Parathyroid adenomas are of monoclonal origin, but it does not exclude influence by both stimulatory and inhibitory factors regulating neo- plastic [...]
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