Diagnosis The diagnosis of primary hyperparathyroidism is generally very straightforward, even though there are many causes of hypercalcemia. Since in primary hyperparathyroidism, parathyroid hormone (PTH) is oversecreted, a PTH immunoassay that reliably detects this increased PTH production is a cornerstone of diagnosis. PTH levels by currently available immunoradiomet- ric assay (IRMA) have the requisite sensitivity [...]
One meta-analysis addressed the effect of vitamin D on the risk of falling in older persons. Based on 5 RCTs (n = 1237), vitamin D reduced the risk of falling by 22% (pooled corrected OR = 0.78; 95% CI [0.64, 0.92]) compared to calcium or placebo (10, 16, 20-22). Subgroup analyses suggested that the reduction [...]
Maintenance of musculoskeletal function and fall prevention are important public health targets in a rapidly aging population. Sarkopenia is prevalent in older persons and resulting in falls among 30% percent of those 65 years or older, and 4050% of those 80 years or older. Several beneficial effect of vitamin D have been described, the most [...]
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