17 Sep

Effect of Long-term Salmeterol Therapy Compared With As-Needed Albuterol Use on Airway Hyperresponsiveness: Conclusion

Effect of Long-term Salmeterol Therapy Compared With As-Needed Albuterol Use on Airway Hyperresponsiveness: ConclusionIn contrast to reports by Sears et al and Taylor et al, recent reports by Drazen et al and Chapman et al did not show deleterious effects of regular use of albuterol on asthma control when compared to as-needed use over either a 4- or 16-week treatment period. It has been suggested however, that results with short-acting inhaled P2-agonists cannot be generalized to the use of long-acting inhaled P2-agonists such as salmeterol. asthma mist asthma relief

The results of the present study, however, show no deleterious effects of longterm salmeterol therapy and indicate that regular use resulted in sustained improvements in pulmonary function and asthma symptom control. Bronchial hyperreactivity or progressive reduction in broncho-protection did not increase following 24 weeks of therapy compared with assessments following 4 weeks of therapy.
Patients in this study were not receiving inhaled corticosteroids. In a steroid-naive population such as this, deterioration from asthma, as indicated by increased use of short-acting P-agonists, would indicate the necessity to institute treatment with inhaled corticosteroids. Combined use of long-acting P-agonists and inhaled corticosteroids, as recommended in current asthma management guidelines, has been shown to provide effective control of both the inflammatory and the bronchospastic components of asthma.
In summary, long-term use of a salmeterol aerosol (42 ^g twice daily) resulted in sustained improvements in pulmonary function and asthma symptom control with no increase in bronchial hyperreactivity or progressive reduction in bronchoprotection. No evidence was present of a rebound increase in bronchial hyperresponsiveness or masking of deterioration from asthma after cessation of salmeterol treatment. Salme-terol treatment does not lead to clinical instability or vulnerability to unpredictable asthma attacks.

Categories: Airway
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