16 Sep

Effect of Long-term Salmeterol Therapy Compared With As-Needed Albuterol Use on Airway Hyperresponsiveness: Outcome

If worsening bronchial responsiveness was masked by the bronchodilating properties of salmeterol, an increase in hyperresponsiveness would be expected during the posttreatment period. In this study, mean levels of bronchial responsiveness to methacholine remained above baseline levels during the posttreatment period, providing no evidence for a rebound increase in bronchial hyperresponsiveness after cessation of salmeterol therapy.
The effects of salmeterol use on asthma control observed in the present study are consistent with previous studies that have demonstrated sustained improvements in pulmonary function for up to 1 year with no evidence of declining pulmonary function, increased use of supplemental albuterol, or increased incidence of asthma exacerbations. In this study, patients receiving salmeterol reported fewer exacerbations than placebo-treated patients during both treatment and posttreatment, although the difference was not statistically significant. natural inhalers for asthma

This reduction in exacerbations with salmeterol is consistent with the results seen in the year-long study by Britton et al, where the rate of exacerbations in patients receiving salmeterol fell during the 12-month treatment period, suggesting that regular salmeterol use is not associated with worsening asthma. Additional indicators of worsening asthma, including declines in PEF, increases in asthma symptoms, and increases in supplemental doses of albuterol, were improved over baseline levels during the posttreatment period. The treatments were well tolerated, with similar numbers of adverse events reported for both treatments. In both treatment groups, cough was the most common adverse event suspected of being related to the study drug, with five cases in the placebo group and three cases in the salmeterol group.

Categories: Airway
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