Archive for the 'Aspergillosis' Category

30 Sep

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis: Conclusion

Nepomu-ceno et al also recently reported the efficacy of itraconazole in 16 patients with cystic fibrosis and ABPA, as judged by fewer acute episodes of ABPA despite a reduction in the average daily oral steroid dose. Germaud et al noted the advantage of associating itraconazole with corticosteroid treatment in six patients with ABPA, and the […]

29 Sep

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis: Discussion

Our study demonstrates that itraconazole is an effective treatment of ABPA, allowing a significant improvement of clinical symptoms, a reduction of the mean dose of oral glucocorticoids, and a partial but significant improvement of pulmonary function tests. Because ABPA is a rare and chronic disease that spreads its course over many years, it is difficult […]

28 Sep

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis: Results

During the first 2-year reference period, the number of exacerbations of ABPA per year was 2.4 ± 0.2. Four patients had three or more exacerbations per year. The values of FEV1, FVC, and forced expiratory flow after 25 to 75% of vital capacity has been expelled ( FEF25_75%) at the beginning of the study and […]

27 Sep

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis: Materials and Methods

Study Design During the initial 2-year reference period, the patients were treated with inhaled glucocorticoid and short acting p2-agonists; 12 out of 14 were taking long-term oral glucocorticoids (prednisolone). The oral glucocorticoids were adjusted to the lowest dose to obtain adequate clinical control, but they were reintroduced at a higher dose (1 mg/kg/d) when acute […]

26 Sep

Effects of Itraconazole Therapy in Allergic Bronchopulmonary Aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction related to the presence of Aspergillus fumigatus colonizing the bronchial tree. ABPA is a rare etiology of asthma, but it must be thought of in severe asthma or glucocorticoid-dependent asthma. Treatment still represents the dark area in our knowledge of ABPA, Although the efficacy of oral glucocorticoids in […]

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