Archive for the 'cancer' Category

24 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Conclusion

Based on the multivariate Cox analyses, one can conclude that pleural disease involvement, LDH level >500 IU/L, poor PS, chest pain, platelet count >400,000/jjlL, nonepithelial histology, and increasing age older than 75 years independently predict poorer survival. Patient groups with similar prognoses were developed using exponential regression trees. This method generated six patient groups with […]

22 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Discussion

Numerous articles have examined the impact of various clinical factors on the prognosis or survival of patients diagnosed as having mesothelioma. Table 5. Qf these articles, along with the time period during which these patient cohorts were diagnosed and the number of patients included in that cohort. The article by Spirtas et al,31 which reported […]

20 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Multivariate Analyses With Adjustment for Study Arm

A Cox regression model was used to determine which terminal nodes to combine or amalgamate without significantly reducing the overall log-likelihood for the model. Table 4 describes the resulting six prognostic groups, and Figure 2 shows the Kaplan-Meier survival curve for each of these subgroups. The patient subgroup with the best prognosis (group 1 in […]

18 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Multivariate Analyses Without Adjustment for Study Arm

Several important prognostic factors were not collected on patients from all studies. Hence, the multivariate Cox regression analyses considered two sets of analyses: (1) an analysis limited to variables collected on all studies, and (2) an analysis limited to studies (8833, 8933, 9031, 9131, and 9234) on which information on all variables was available. Table […]

16 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Results

Patient Demographics The profile of patients with mesothelioma treated on CALGB protocols is summarized in Table 2. Patients were generally male (83%), had good PS (ECOG PS^O or 1; 81%), presented with chest pain (60%) or dyspnea (70%) after experiencing symptoms for <3 months (46%), had a history of asbestos exposure (62%) or smoking (72%), […]

14 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Pretreatment Patient Characteristics

Information concerning the primary site of the mesothelioma was not available from computer files for this retrospective analysis; rather information about anatomic sites of disease involvement was available. Hence, the variable describing pleural disease involvement is an indicator of whether mesothelioma involved the pleura. antibiotics online Institutional normal ranges were not available for LDH. Hence, […]

12 Apr

Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group B: Materials and Methods

The study 8435 was conducted as a randomized phase II study; whereas 8638, 8833, 9031, and 9234 were conducted as singlearm studies. Both 8933 and 9131 were originally designed as single-arm studies; however, a second arm replaced the original arm in each study when the experimental regimen was modified by amendment. The dose of trimetrexate […]

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