Archive for the 'Diseases' Category

01 Feb

Integrating laboratory and epidemiological techniques: FUTURE DIRECTIONS

Although the use of highly active antiretroviral therapy (HAART) has led to a reduction in HIV-1 related morbidity and mortality in the developed world, HAART has created a unique set of chal­lenges – the development of resistance to antiretroviral drugs that greatly affect the treatment of HIV-1 infection. Much more remains to be learned about […]

31 Jan

Integrating laboratory and epidemiological techniques: DISCUSSION part 2

While the CHSDRSP reference services and the pilot study have identified HIV-1 non-B subtypes in most provinces, the present results suggest that the proportion of non-B subtypes varies between geographic regions. The CHSDRSP pilot study identified no non-B subtypes from Newfoundland, whereas up to 15.6% of the samples from British Columbia belonged to this group. […]

30 Jan

Integrating laboratory and epidemiological techniques: DISCUSSION

At the end of 1996, there were approximately 40,000 Cana­dians living with HIV infection. The number of incident HIV infections in Canada for 1996 was approximately 4200, higher than the average of 2500 to 3000/year from 1989 to 1994. An analysis of the distribution of incident infec­tions by exposure category illustrates a changing face of […]

29 Jan

Integrating laboratory and epidemiological techniques: HIV-1 subtypes for CHSDRSP samples from British Columbia part 2

Logistic regression to determine the simultaneous effects among variables indicated that age and year of first testing positive for HIV were significantly associated with a non-B outcome (P=0.009 and P=0.0003, respectively) in the sam­pled population. Compared with the B-subtype, the likelihood of a non-B subtype among those diagnosed with HIV was 1.11 times greater for […]

28 Jan

Integrating laboratory and epidemiological techniques: HIV-1 subtypes for CHSDRSP samples from British Columbia

Stored serum specimen from individuals newly diag­nosed with HIV in 1996, 1997, 1998, and up to March 15, 1999 were included in this pilot study. The samples represent be­tween 4% to 6% of HIV-positive tests reported by British Colum­bia to the Division of HIV Surveillance, Bureau of HIV, STD and TB for each year, and […]

27 Jan

Integrating laboratory and epidemiological techniques: CHSDRSP Pilot Study

At a national consensus meeting in January 1998 to dis­cuss the feasibility of the goals of CHSDRSP, working groups including federal, provincial and territorial stakeholders rec­ommended piloting the surveillance methodologies at one or more sites before implementing CHSDRSP nationwide. The five sites included in this pilot phase were British Columbia, Alberta, Saskatchewan, Manitoba and Newfoundland. […]

26 Jan

Integrating laboratory and epidemiological techniques: CHSDRSP INITIATIVES

Laboratory References Services, Bureau of HIV/AIDS, STD and TB, LCDC Provincial health laboratories (PHLs) and Canadian Blood Service are involved in HIV testing of individuals, and as such are key partners to CHSDRSP. A number of factors that result in unusual serological responses are relatively well estab­lished (seroconversion and cross-reactivity to HIV-2) and are recognized […]

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