Archive for the 'Gastroenterology' Category

05 May

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis: DISCUSSION Part 3

Unfortunately, the management of patients with SCLC and paraneoplastic syndrome has been difficult. The use of steroids, plasma exchange and intravenous immunoglobulin has been found to be unsuccessful. The hypothesis that the gastrointestinal manifestations associated with the paraneoplastic syndrome are caused by an autoimmune process has prompted the use of immunosuppressants. While there have been […]

03 May

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis: DISCUSSION Part 2

The principle Hu antigens in humans are HuD, HuC, and Hel-N1. Hu antigens are 35 to 40 kD proteins expressed both in the nucleus and in the cytoplasm of all neurons of the central and peripheral nervous system, as well as in tumour tissue. The antibody received the name Hu from the first two letters […]

02 May

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis: DISCUSSION Part 1

Paraneoplastic syndromes are disorders that result from the distant effects of an underlying malignancy, and are not related to the local effects of the primary tumour or its metastases. In the majority of patients with gastrointestinal manifestations, the evolution of symptoms and signs is subacute (less than six months). Reports of symptoms developing over 24 […]

28 Apr

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis: CASE PRESENTATION Part 1

A 57-year-old woman with a six-month history of weight loss was transferred to the authors’ facility for further investigations. She was previously well, with no specific gastrointestinal illnesses. Past medical history was significant for Graves’ disease, which had been treated with thyroidectomy and thyroid replacement therapy. Her thyroid disease was under control. Diabetes was not […]

26 Apr

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis

Paraneoplastic syndromes result from the distant effects of underlying malignancy, and are not related to the local effects of the primary tumour or its metastases. Paraneoplastic neurological syndromes may affect any part of the nervous system. The most common neurological syndromes are paraneoplastic sensory neuropathy and paraneoplastic encephalomyelitis. Other manifestations include cerebellar ataxia, limbic encephalitis, […]

15 Apr

CAG News Page: SUMMARY AND THE MOVE FORWARD

SUMMARY The results of this survey have provided sufficient data to guide the CAG in the development of its educational programs. It is hoped that this will also be of interest to the pharmaceutical industry and perhaps encourage future targeted, cosponsored, accredited events for CAG members. Clearly, there is interest in some of the traditional […]

14 Apr

CAG News Page: LIMITATIONS OF THE SURVEY

We have heard from approximately one-third of the membership; conversely we have not heard from the remaining two-thirds. Given that 60% of the respondents have a university affiliation, it is likely that the results of this survey are biased toward hospital-based, urban, male, academic gastroenterologists. In future surveys, we will need to better target community-based members […]

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