HIV/AIDS News & Information

The ICER of C-UBT versus serology ranged from $57/cure to over $32270/cure in sensitivity analysis and ex­ceeded $2000/cure only with variation in C-UBT cost and serology specificity (Table 5). In no case did C-UBT domi­nate serology. However, serology became dominant over 13C-UBT when the specificity of 13C-UBT fell below 81%. Two-way sensitivity analysis: Because the [...]

RESULTS Base case scenario: The number of endoscopies per 1000 pa­tients was lowest with the C-UBT strategy, higher with serology and highest with empirical ranitidine therapy (Table 3). The number of H pylori eradica­tion regimens prescribed per 1000 patients was lowest with empirical ranitidine (200.1), highest with serology and intermediate with the 13C-UBT. In the [...]

Several sources were used to estimate locally relevant direct costs for the resources consumed in the model (Table 2). Wholesale drug costs were determined through a survey of local pharmacies including the Hamilton Health Sciences Corporation (McMaster Site) Outpatient Phar­macy, Hamilton, Ontario. A 10% pharmacy markup was added to the wholesale price, as well as [...]

In each arm, the first-line regimen for H pylori eradication was omeprazole 20 mg, clarithromycin 500 mg and metroni­dazole 500 mg bid for seven days (OCM). The second-line regimen, used for OCM failures, was omeprazole 20 mg bid, clarithromycin 500 mg bid and amoxicillin 1000 mg bid for seven days. When a third attempt at [...]

Decision tree: The decision-analytic model was constructed using DATA software (TreeAge Software Inc, Williams- town, Massachusetts). A hypothetical cohort of 1000 pa­tients under the age of 50 years who had presented to their primary care practitioner with a new complaint of dyspepsia and did not use nonsteroidal anti-inflammatory drugs was used. Three initial management strategies [...]

UBT is considered by many to be the gold standard non- invasive test for the detection of active H pylori infection. After a 4 h fast, the patient ingests carbon- or carbon- labelled urea, which is metabolized to carbon dioxide by the H pylori-associated urease. The labelled carbon dioxide is then absorbed, and the increased [...]

Test and treat strategies for Helicobacter pylori in uninvestigated dyspepsia: A Canadian economic analysis. By convention, the term ‘dyspepsia’ is used to describe a symptom complex of chronic or recurrent pain or dis­comfort in the upper abdomen that is attributable to the up­per gastrointestinal tract. Although variably defined in the literature, dyspepsia imposes a substantial [...]