Archive for the 'Health' Category

14 Dec

Reasons for Non-use of Proven Interventions for Hospital Inpatients

INTRODUCTION Consensus guidelines have been developed in both the United States and Canada recommending the use of proven clinical interventions for various disease states, to improve patient safety and quality of care. Despite these publications, a large gap still exists between the number of patients who meet the criteria for use of these interventions and […]

08 Dec

Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride: DISCUSSION

In this study, solutions of 5-fluouracil 8 mg/mL in NS in PVC bags were stable after freezing and storage for 79 days at —20°C, thawing in a microwave oven, and refrigeration for a further 28 days. We believe that the assay was stability- indicating. Although the absence of degradation peaks after heating in acidic and […]

07 Dec

Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride: RESULTS

Assay Validation Linear regression analysis of the peak area yielded a correlation coefficient (r2) of 0.9976 in the range of 1 mg/mL to 35 mg/mL, which indicates good linearity of the assay. The within-day relative SD values (n = 10) were 2.80% for the 35 mg/mL control solution, 2.90% for the 25 mg/mL control solution, […]

06 Dec

Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride: Method part 2

Samples were assayed by high-performance liquid chromatography (HPLC; Alliance model 2695 chromatography system, Waters Corporation, Milford, Massachusetts) with a photodiode array detector (model 996, Waters Corporation) and data acquisition and processing module software (Empower

05 Dec

Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride: MATERIALS AND METHODS

Preparation of Solutions 5-Fluorouracil (Fluracedyl, 1000 mg in 20 mL; Teva Pharma Belgium SA Wilrijk, Belgium, lot 06 H 28 PA) was diluted in 100 mL NS in a PVC bag (Macopharma Benelux, Mouscron, Belgium, lot 07 F 08 D, expiry June 2009) to obtain an approximate final concentration of 800 mg/100 mL (8 mg/mL). […]

04 Dec

Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride

INTRODUCTION 5-Fluorouracil, an analogue of the pyrimidine uracil and one of the oldest anticancer agents, acts as an antimetabolite drug. It remains the standard therapy for advanced colorectal cancer and is also one of the primary agents used to treat head, neck, and breast cancer. The drug is usually diluted for parenteral injection with 0.9% […]

23 Nov

Development and Initial Evaluation: DISCUSSION part 2

The raison d’etre of contemporary pharmacists is to improve the quality of patients’ lives. Health outcomes (including clinical, humanistic, and economic out­comes) must be measured to provide feedback to the caregiver responsible for the patient, as well as to the administrators who determine the relative spending advantages of one health service over another. More than […]

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