Archive for the 'Hepatic Dysfunction' Category

28 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome: Conclusion

The liver has a significant role in host defense mechanisms. Alteration in reticuloendothelial cell function may be involved in potentiating infectious processes. The sepsis syndrome is a major complication of ARDS and contributes to its mortality. Intact hepatic function may be important in preserving the systemic response to infection. Additionally, the liver may protect the […]

27 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome: Discussion

The magnitude of disturbance in oxygenation or of renal dysfunction did not differentiate survivors from those who died. However, at the time the ARDS was identified and during the subsequent week, indices of hepatic damage or dysfunction were more abnormal in patients who died than in survivors. Our inability to differentiate survivors from nonsurvivors using […]

26 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome: Hyperbilirubinemia

Serum bilirubin values averaged 1.9 mg/dl (range 0.6-11.6 mg/dl). Hyperbilirubinemia was associated with a poor outcome. Survivors bilirubin values were lower at study entry than nonsurvivors (1.3 ±0.9 mg/dl vs. 2.3 ± 2.8 mg/dl), a difference which persisted for the first study week (p <0.01) (Fig 2). Nine of 17 (53 percent) patients with normal […]

25 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome: Results

None of the patients had previous liver disease and only three had history of alcohol abuse. Forty percent of survivors and 43 percent of those who died received parenteral nutrition. Serum values outside the hospital laboratory’s normal range were considered abnormal. Serum abnormalities suggested hepatocyte damage or dysfunction in all 24 patients at the time […]

24 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome: Methods

Clinical criteria of sepsis and septic syndrome as previously defined by Bone et allf were used. Patients were excluded if they previously had severe interstitial lung disease, had received systemic corticosteroid therapy within seven days of identification, were not expected to survive 30 days for reasons other than ARDS, of if the ARDS was not […]

23 Oct

Hepatic Dysfunction in the Adult Respiratory Distress Syndrome

The adult respiratory distress syndrome (ARDS) clinically manifests as hypoxemia, decreased pulmonary compliance, and diffuse radiographic pulmonary infiltrates. Despite better understanding of risk factors and mechanisms of lung injury, and improved techniques of support, the mortality of patients with ARDS has not changed since its initial description. Early death in ARDS results from the underlying […]

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