Archive for the 'Hypoxia' Category

09 Jun

Hypoxia-Mediated Modulation of Vascular Function—Implications for Organ Preservation and Thrombogenesis: Hypoxia-Mecliated Induction of Fibrin Formation: Induction of Tissue Factor

Vascular fibrin deposition was observed using a fibrin-specific antibody, and immunoblotting of lung extracts with an antibody directed against fibrin gamma-gamma chain crosslinks also showed fibrin in lungs of hypoxic, but not normoxic animals (Fig 4, top). http://asthma-inhalers-online.com Reading here A mechanism likely to be important in triggering the activation of coagulation in hypoxemic vasculature […]

07 Jun

Hypoxia-Mediated Modulation of Vascular Function—Implications for Organ Preservation and Thrombogenesis: Hypoxia-Mediated Induction of Cytokine Expression: IL-6

The underlying mechanism appears to be hypoxia-mediated activation of the transcription factor nuclear factor-IL-6 (NF-IL-6); by electrophoretic mobility shift analysis, nuclear extracts harvested from lung of hypoxic mice showed a band of increased intensity using radiolabeled oligonucleotide corresponding to the NF-IL-6 binding site in the IL-6 promoter (Fig 3, center). Furthermore, transient transfection of endothelial […]

05 Jun

Hypoxia-Mediated Modulation of Vascular Function—Implications for Organ Preservation and Thrombogenesis: P-Selectin Translocation in Hypoxic Endothelial Cells: Implications for Leukostasis in Preserved Cardiac Graft

Although we initially expected that the principal effects of cAMP/cGMP analogs would involve rapid changes in vascular tone, their beneficial effects appear to be mediated by other mechanisms. For example, excellent vasodilation consequent to inclusion of hydralazine in the preservation solution conferred no advantage for organ survival in a lung transplant model. This led us […]

03 Jun

Hypoxia-Mediated Modulation of Vascular Function—Implications for Organ Preservation and Thrombogenesis: Results

Hypoxia-Mediated Suppression of the cAMP Second Messenger System: Implications for Cardiac Graft Preservation The cAMP second messenger system exerts effects on signaling pathways related to many critical vascular properties, including vascular permeability, thrombogenicity, tone, and leukocyte interactions. Exposure of cultured endothelial cells to diminishing concentrations of oxygen resulted in a fall in intracellular cAMP and […]

01 Jun

Hypoxia-Mediated Modulation of Vascular Function—Implications for Organ Preservation and Thrombogenesis

Roger S. Mitchell Lecture The adaptive response to oxygen deprivation involves multiple components. The best-characterized mechanism triggered by hypoxia/hypoxemia is expression of erythropoietin, resulting from de novo transcription and translation and due to the transcription factor hypoxia-inducible factor-1. The same mechanism appears to underlie other essential adaptive responses, such as enhanced utilization of glucose as an energy […]

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