Archive for the 'Lung Cancer' Category

25 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Conclusion

Overall survival at 2 years in our study was 31% for the entire group and 39% for clinical stage I patients. These survival rates are low, but most deaths occurred in patients who had no evidence of recurrent cancer. The low survival rates, then, are probably related to the age and poor pulmonary function of […]

24 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Outcome

Charged-particle beams such as proton beams have physical properties that allow tumor irradiation with maximal sparing of normal tissue. These properties are superior to what can be accomplished with conventional x-ray beams. Accordingly, we employed proton-beam radiotherapy to deliver high-dose tumor irradiation while simultaneously reducing the amount of normal lung irradiation, in the hope of […]

23 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Discussion

A difficult clinical situation arises when a patient with an early-stage lung tumor is medically unfit for an operation. The most common conditions that render patients medically inoperable are advanced COPD, cardiovascular disease, and poor overall medical condition. Many of these patients are referred for definitive radiotherapy because it is believed that such treatment will […]

22 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Actuarial overall survival

Actuarial overall survival was calculated utilizing the Kaplan-Meier technique (Table 3). Actuarial overall survival at 2 years for the entire group was 31%. For the clinical stage I patients, the actuarial 2-year overall survival rate was 39%. The 2-year survival rate for stage IIIa patients was 13%. The disease-free survival rate at 2 years was […]

21 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Results

Thirty-seven patients were enrolled from July 1994 to January 1998. Two patients had follow-up of < 3 months and were deemed unevaluable for acute toxicity and tumor response. Thus, 35 evaluable patients were included for analysis with follow-up periods ranging from 3 to 45 months (median, 14 months). The average patient age at enrollment was […]

20 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Technique of Proton Irradiation

Technique of Proton Irradiation Preparation for proton radiation therapy began with construction of a custom-made full-body mold, which was used to ensure reproducible patient immobilization. A CT scan of the chest was then obtained with the patient in the mold (treatment position), and a computerized, three-dimensional treatment plan was developed. From this plan, a wax […]

19 Sep

Proton-Beam Radiotherapy for Early-Stage Lung Cancer: Materials and Methods

The Institutional Review Board at Loma Linda University approved a prospective trial that began enrolling patients in July 1994. Eligibility criteria included histologic confirmation of nonsmall cell lung carcinoma (clinical stage I to IIIa) and medical contraindications to surgical resection and/or patient refusal of such treatment. Most patients in this study had significant underlying COPD […]

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