Archive for the 'Pneumonia' Category

13 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Conclusion

Other studies have demonstrated no increased risk of AIDS-related complications associated with adjunctive corticosteroid therapy. In a retrospective study of 144 patients with HIV-associated PCP, there was no difference in the risk of tuberculosis between the 94 patients who received steroids and the 50 who did not. In another retrospective study from Spain, there was […]

11 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Outcome

There was a significant increase in esophageal candidiasis and a trend toward an increase in oral candidiasis. The difference in tuberculosis was significant, but the numbers were small, and the timing of both cases made it unlikely that corticosteroid therapy had contributed to the development of disease. Nevertheless, the power of this study to detect […]

09 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Discussion

The effectiveness of adjunctive corticosteroids in reducing morbidity and mortality from PCP has been demonstrated in a number of clinical trials, and adjunctive corticosteroids are now recommended for early treatment of patients with moder-ate-to-severe PCP, as defined by an arterial oxygen pressure of < 70 mm Hg or an arterial-alveolar gradient of > 35 mm […]

07 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Estimate of survival

By Kaplan-Meier analysis, there were no differences in times to CMV, MAC, cryptococcal meningitis, toxoplasmosis, KS, or oropharyngeal candidiasis following PCP (p > 0.05). There was a difference in the risk of developing esophageal candidiasis over time by Kaplan-Meier analysis. By 1 year after PCP, 14% of the steroid recipients and 9% of the nonrecipients […]

05 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Results

A total of 174 patients had a first episode of PCP after being enrolled in the clinic and entering the cohort. Of those, 53 (31%) received adjunctive corticosteroids and 120 (69%) did not. Criteria for use of steroids in patients with PCP were consistent with standard treatment recommendations (arterial oxygen pressure < 70 mm Hg […]

03 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Analysis

Analysis Our analyses focused on the 174 patients who had an episode of PCP after being enrolled in the clinic and entering the cohort. The index episode of PCP was the first episode experienced by the patient since entering the cohort but was not necessarily the patient’s first episode of PCP overall. An additional 297 patients had […]

01 Jul

Treatment of Pneumocystis carinii Pneumonia on Mortality and Subsequent Complications: Materials and Methods

In addition, the names of patients whose vital status is unknown for >12 months are searched for in the death records of the Maryland Bureau of Vital Records and the National Death Index. Nurses and physicians associated with the HIV clinic check the validity of a 10% sample of all collected data. If systematic error […]

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